Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

Scope A high fructose and galactose intake show adverse metabolic effects in animal models humans, but it is yet unknown if addition of fermentable dietary fiber can mitigate such effects. This study investigate the intakes galactose, with/without added fructooligosaccharides (FOS), on factors, inflammation, gut integrity markers rats. Methods Results Rats (n = 6/group) receive different carbohydrates at isocaloric conditions for 12 weeks as follows: 1) starch (control), 2) fructose, 3) 4) + FOS (FOS control), 5) FOS, 6) together with a amount n-6 polyunsaturated fatty acids (n-6 PUFA) all diets except 7) olive oil (negative control). The rats fed exhibit lower body weight than other groups. High-galactose has more pronounced factors permeability high-fructose diets. High-fructose less effect these selected markers. No differences inflammatory are detected any Conclusions results suggest potential markers, not inflammation. However, several mechanisms play, general net difficult to determine conclusively tested.